Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumption revealed its inverse correlation with that of diabetes mellitus, various cancer lines, Parkinsonism, and Alzheimer's disease (Butt and Sultan 2011).
On the other hand, their higher levels raise serum cholesterol, posing a possible threat to coronary health, for example, myocardial and cerebral infarction, insomnia, and cardiovascular complications. Caffeine also affects adenosine receptors and its withdrawal is accompanied with muscle fatigue and allied problems in those addicted to coffee. Coffee is the leading worldwide beverage after water and its trade exceeds US $10 billion worldwide. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health promoting potential; however, some researchers have argued about the association of coffee consumption with oral cancer prevention. Al Dakkak. 2011 has investigated this argue in an evidence based literature review. He found that "Caffeinated coffee" intake was inversely associated with the risk of cancer of the oral cavity and pharynx: for an increment of one cup per day. This was also evident but in lower degree for individuals who consume more than 4 cups per day versus non-drinkers. This latter estimate was consistent for different anatomic sites like oral and pharyngeal cancer but no association of caffeinated coffee drinking was found with laryngeal cancer.
Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk Al Dakkak has concluded that his pooled analysis of case-control studies supports the hypothesis of an inverse association between caffeinated coffee drinking and risk of cancer of the oral cavity and pharynx.
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